All-trans-retinoic acid-induced myositis in a child with acute promyelocytic leukemia.

An trans-retinoic acid in the treatment of promyelocytic leukaemia - a case report

Acute Promyelocytic Leukaemi.a (APML) is an uncommon type of acute non-lymphocytic leukaemia (ANLL)l. Treatment of APML is associated with significant mortality and morbidity. Ten to twenty per cent of the patients die early of fatal haemorrhage resulting from coagulopathy and sepsis. An alternative approach to the treatment of APML has centered on the use of differentiating agents to induce re...

THE RELATIONSHIP BETWEEN THE LEVELS OF GRANULOCYTE-COLONY STIMULATING FACTOR AND LEUKOCYTOSIS INDUCED BY ALL-TRANS RETINOIC ACID IN ACUTE PROMYELOCYTIC LEUKEMIA Wu Wen. Division of Haematology/Oncology and Bone Marrow Transplant Unit,UDM,QMH Differentiation therapy with all-trans retinoic acid

Cytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients

Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...

Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome

Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myo...

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid receptor alpha rearrangement. This rearrangement interacts with several proteins, including the native promyelocytic leukemia gene, thus causing ...